The New Mexico Tumor Registry (NMTR) was established in 1966 and serves as a population-based cancer registry for the State of New Mexico. The NMTR provides high quality cancer surveillance data to support scientific research and a broad spectrum of cancer control activities. The NMTR is a founding member of the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program and has continuously participated in that program since 1973. The NMTR also collaborates with the Arizona Cancer Registry and the Indian Health Service to provide population-based cancer surveillance for Native American populations in Arizona. Cancer surveillance in New Mexico is conducted in accordance with standards set by the SEER Program, the Centers for Disease Control and Prevention, the North American Association of Central Cancer Registries, and the American College of Surgeons.